Description
The project aims to improve Nuclear Magnetic Resonance (NMR) fragment screening in drug development by developing a high-sensitivity and high-throughput methodology based on the ^19F steady-state free precession (SSFP) approach. Overcoming previous limitations in sensitivity and spectral resolution, this method enables rapid and reliable detection of small molecule interactions with biological targets, including complex and previously difficult-to-study proteins.
Simultaneously, the project aims to develop a flexible, fluorinated fragment library specifically tailored for SSFP screening. This will enable efficient exploration of chemical space and automated analysis, strengthening drug discovery potential for both academia and industry.
The Achievable Results
Improve the ^19F SSFP NMR screening method and develop an optimized fluorinated fragment library to significantly increase the speed and efficiency of drug candidate identification.
The Anticipated Benefit
To promote the development of new, more effective medicines, including for complex diseases such as neurodegenerative disorders, while simultaneously strengthening innovation and the development of the pharmaceutical industry.